ABSTRACT
Objective@#To analyze the emotional and behavioral problems and associated factors of the only and non only child, and to provide some clues for further monitoring and intervention of psychological and behavioral development among preschool children.@*Methods@#Using a convenience sampling method, a total of 45 065 children enrolled in 153 kindergartens in 23 districts and counties of Chengdu were selected from May to June 2021 to investigate demographic characteristics and children s psycho behavioral development through online questionnaires filled out by their guardians. The Chi square tests were used to analyze whether the differences in abnormality rates of each dimension were statistically significant between the only and non only children. The emotional and behavioral problems of only children and non only children were analyzed by propensity score measurement.@*Results@#The detection rate of abnormal emotional behavior problems in children was 6.10%, including 6.34% in the only child group and 5.84 % in the non only child group. After matching, total difficulty score, and scores of emotional symptoms, conduct problems, hyperactive attention deficit, peer interaction, and social behavior differed between the only child group and the non only child group ( t =9.91, 8.97, 3.91, 15.57, -5.46, 4.08, P <0.01).@*Conclusion@#In terms of the total score of difficulties, emotional symptoms, moral problems, and hyperactivity attention defects, the non only child is better than the only child，but the opposite is true in terms of peer interaction and social behavior. Mental health conditions among the only child should be paid more attention. Whether or not the only child should be taken as an important consideration for preschool children s mental health care.
ABSTRACT
Ischemic stroke(IS)is one of the main causes of long-term morbidity and mortality all over the world, which severely threatens the public health. It has been demonstrated that IS is accompanied by severe neuronal loss that leads to irreversible damage to brain. Thus, effective regeneration of neurons has great potential to the treatment of IS. In recent decades, a large number of studies have shown that newly-generated neurons can exert beneficial effects on repairing the neural damage such as the damaged hippocampus, cortex and striatum after IS. However, although the ischemic injury can activate endogenous neural stem cells to some extent, the stroke-related pathological circumstance can significantly reduce the survival of endogenous neural stem cells, greatly attenuating the neurogenesis- related protective effects on ischemic outcome. Therefore, it is of great clinical importance to seek potential drugs which can promote endogenous neurogenesis. Recent studies have indicated that the anti- apoptosis drugs, endogenous growth factors as well as a series of the bioactive chemical constituents of traditional Chinese medicines and the compound traditional Chinese medicine preparations can protect the brain against the IS by promoting the endogenous neurogenesis. In this review, we summarize the changes in the endogenous neurogenesis induced by the IS and potential drugs which promote the endogenous neurogenesis during the process of IS, hoping to provide a reference for the clinical treatment of IS.